Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression

Glucocorticoids are the most effective antiinflammatory agents for the treatment of chronic inflammatory diseases even though some diseases, such as chronic obstructive pulmonary disease (COPD), are relatively glucocorticoid insensitive. However, the molecular mechanism of this glucocorticoid insens...

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Bibliographic Details
Main Authors: Ito, Kazuhiro, Yamamura, Satoshi, Essilfie-Quaye, Sarah, Cosio, Borja, Ito, Misako, Barnes, Peter J., Adcock, Ian M.
Format: Online
Language:English
Published: The Rockefeller University Press 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118081/