Uptake of Leishmania major by dendritic cells is mediated by Fcγ receptors and facilitates acquisition of protective immunity
Uptake of Leishmania major by dendritic cells (DCs) results in activation and interleukin (IL)-12 release. Infected DCs efficiently stimulate CD4− and CD8− T cells and vaccinate against leishmaniasis. In contrast, complement receptor 3–dependent phagocytosis of L. major by macrophages (MΦ) leads exc...
| Main Authors: | , , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2006
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118064/ |