Transformation of NIH 3T3 cells with basic fibroblast growth factor or the hst/K-fgf oncogene causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin
When NIH 3T3 cells were transfected with the cDNA for basic fibroblast growth factor (bFGF), most cells displayed a transformed phenotype. Acquisition of a transformed phenotype was correlated with the expression of high levels of bFGF (Quarto et al., 1989). Cells that had been transformed as a resu...
| Format: | Online |
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| Language: | English |
| Published: |
The Rockefeller University Press
1989
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2115849/ |