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pubmed-2114830
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| recordtype |
oai_dc
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| spelling |
pubmed-21148302008-05-01 Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans Articles The establishment of cell division axes was examined in the early embryonic divisions of Caenorhabditis elegans. It has been shown previously that there are two different patterns of cleavage during early embryogenesis. In one set of cells, which undergo predominantly determinative divisions, the division axes are established successively in the same orientation, while division axes in the other set, which divide mainly proliferatively, have an orthogonal pattern of division. We have investigated the establishment of these axes by following the movement of the centrosomes. Centrosome separation follows a reproducible pattern in all cells, and this pattern by itself results in an orthogonal pattern of cleavage. In those cells that divide on the same axis, there is an additional directed rotation of pairs of centrosomes together with the nucleus through well-defined angles. Intact microtubules are required for rotation; rotation is prevented by inhibitors of polymerization and depolymerization of microtubules. We have examined the distribution of microtubules in fixed embryos during rotation. From these and other data we infer that microtubules running from the centrosome to the cortex have a central role in aligning the centrosome-nuclear complex. The Rockefeller University Press 1987-11-01 /pmc/articles/PMC2114830/ /pubmed/3680373 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
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| repository_type |
Open Access Journal
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| institution_category |
Foreign Institution
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| institution |
US National Center for Biotechnology Information
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| building |
NCBI PubMed
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| collection |
Online Access
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| language |
English
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| format |
Online
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| title |
Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans
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| spellingShingle |
Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans
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| title_short |
Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans
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| title_full |
Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans
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| title_fullStr |
Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans
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| title_full_unstemmed |
Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans
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| title_sort |
determination of cell division axes in the early embryogenesis of caenorhabditis elegans
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| description |
The establishment of cell division axes was examined in the early embryonic divisions of Caenorhabditis elegans. It has been shown previously that there are two different patterns of cleavage during early embryogenesis. In one set of cells, which undergo predominantly determinative divisions, the division axes are established successively in the same orientation, while division axes in the other set, which divide mainly proliferatively, have an orthogonal pattern of division. We have investigated the establishment of these axes by following the movement of the centrosomes. Centrosome separation follows a reproducible pattern in all cells, and this pattern by itself results in an orthogonal pattern of cleavage. In those cells that divide on the same axis, there is an additional directed rotation of pairs of centrosomes together with the nucleus through well-defined angles. Intact microtubules are required for rotation; rotation is prevented by inhibitors of polymerization and depolymerization of microtubules. We have examined the distribution of microtubules in fixed embryos during rotation. From these and other data we infer that microtubules running from the centrosome to the cortex have a central role in aligning the centrosome-nuclear complex.
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| publisher |
The Rockefeller University Press
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| publishDate |
1987
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| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2114830/
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| _version_ |
1611413458348146688
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