DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER

DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER

Uridine diphosphate (UDP) glucuronyltransferase activity in chick liver rises at hatching from near zero to adult levels. This rise will occur prematurely in embryo liver during organ culture. Increase in enzyme activity during organ culture differs with embryo age: in liver from 11-day old embryos...

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Main Authors: Burchell, Brian, Dutton, Geoffrey J., Nemeth, Andrew M.
Format: Online
Language:English
Published: The Rockefeller University Press 1972
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2108804/
id pubmed-2108804
recordtype oai_dc
spelling pubmed-21088042008-05-01 DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER Burchell, Brian Dutton, Geoffrey J. Nemeth, Andrew M. Article Uridine diphosphate (UDP) glucuronyltransferase activity in chick liver rises at hatching from near zero to adult levels. This rise will occur prematurely in embryo liver during organ culture. Increase in enzyme activity during organ culture differs with embryo age: in liver from 11-day old embryos it ceases at adult values; in liver from 5-day old embryos it continues to much higher-than-adult levels. Phenobarbital added to culture medium accelerates these rises in enzyme activity and elevates the plateau reached in 11-day embryo liver to that observed in 5-day embryo liver. Kinetic analysis of the changes in enzyme activity induced by phenobarbital during culture suggests that the regulatory mechanisms for enzyme activity are different in 5- and 11-day embryo liver and that these differences reflect developmental changes occurring in ovo. The Rockefeller University Press 1972-11-01 /pmc/articles/PMC2108804/ /pubmed/5076783 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Burchell, Brian
Dutton, Geoffrey J.
Nemeth, Andrew M.
spellingShingle Burchell, Brian
Dutton, Geoffrey J.
Nemeth, Andrew M.
DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
author_facet Burchell, Brian
Dutton, Geoffrey J.
Nemeth, Andrew M.
author_sort Burchell, Brian
title DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
title_short DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
title_full DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
title_fullStr DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
title_full_unstemmed DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
title_sort development of phenobarbital-sensitive control mechanisms for uridine diphosphate glucuronyltransferase activity in chick embryo liver
description Uridine diphosphate (UDP) glucuronyltransferase activity in chick liver rises at hatching from near zero to adult levels. This rise will occur prematurely in embryo liver during organ culture. Increase in enzyme activity during organ culture differs with embryo age: in liver from 11-day old embryos it ceases at adult values; in liver from 5-day old embryos it continues to much higher-than-adult levels. Phenobarbital added to culture medium accelerates these rises in enzyme activity and elevates the plateau reached in 11-day embryo liver to that observed in 5-day embryo liver. Kinetic analysis of the changes in enzyme activity induced by phenobarbital during culture suggests that the regulatory mechanisms for enzyme activity are different in 5- and 11-day embryo liver and that these differences reflect developmental changes occurring in ovo.
publisher The Rockefeller University Press
publishDate 1972
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2108804/
_version_ 1611410227532398592

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