THE MECHANISM OF ACTION OF COLCHICINE : Colchicine Binding to Sea Urchin Eggs and the Mitotic Apparatus

Colchicine forms a complex in vivo with a protein present in fertilized or unfertilized sea urchin eggs; similar binding was obtained in vitro with the soluble fraction from egg homogenates. Kinetic parameters and binding equilibrium constant were essentially the same in vivo and in vitro. The bind...

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Bibliographic Details
Main Authors: Borisy, G. G., Taylor, E. W.
Format: Online
Language:English
Published: The Rockefeller University Press 1967
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107308/