Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ

Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ

The recently characterised 299-residue human XLF/Cernunnos protein plays a crucial role in DNA repair by non-homologous end joining (NHEJ) and interacts with the XRCC4–DNA Ligase IV complex. Here, we report the crystal structure of the XLF (1–233) homodimer at 2.3 Å resolution, confirming the predic...

Full description

Bibliographic Details
Main Authors: Li, Yi, Chirgadze, Dimitri Y, Bolanos-Garcia, Victor M, Sibanda, Bancinyane L, Davies, Owen R, Ahnesorg, Peter, Jackson, Stephen P, Blundell, Tom L
Format: Online
Language:English
Published: Nature Publishing Group 2008
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2104711/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2104711/

Similar Items