The CD38/CD157 mammalian gene family: An evolutionary paradigm for other leukocyte surface enzymes

Human CD38 is the mammalian prototype of a family of phylogenetically conserved proteins which share structural similarities and enzymatic activities involved in the production of an intracellular second messenger with calcium mobilizing effects. Engagement of CD38 by agonistic monoclonal antibodies...

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Bibliographic Details
Main Authors: Deaglio, Silvia, Malavasi, Fabio
Format: Online
Language:English
Published: Springer Netherlands 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096639/