Laminin activates the p185HER2 oncoprotein and mediates growth inhibition of breast carcinoma cells.
The interaction between laminin and the oncoprotein encoded by the c-erbB-2 oncogene was studied in vitro and in vivo in human breast carcinomas. In vitro analysis of breast carcinoma cell lines overexpressing p185HER2 revealed that laminin, but not fibronectin, induced tyrosine phosphorylation and...
| Main Authors: | , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
1996
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074760/ |