A constitutional de novo mutation in exon 8 of the p53 gene in a patient with multiple primary malignancies.
We report a constitutional point mutation of codon 278 in exon 8 of the TP53 gene that has not yet been described as a germ-line mutation. A 52-year-old female developed multiple primary malignancies (liposarcoma, breast cancer, malignant histiocytoma, occult adenocarcinoma). The mutation found in h...
| Main Authors: | , , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
1996
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074589/ |