Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.

The present study investigates the prognostic value of immunohistochemically detected cathepsin D expression in endometrial adenocarcinoma. Patients with surgically treated endometrial adenocarcinoma FIGO stages I-III and consecutive irradiation therapy were included in the study. When we performed...

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Main Authors:	Lösch, A., Kohlberger, P., Gitsch, G., Kaider, A., Breitenecker, G., Kainz, C.
Format:	Online
Language:	English
Published:	Nature Publishing Group 1996
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074555/

id	pubmed-2074555
recordtype	oai_dc
spelling	pubmed-20745552009-09-10 Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer. Lösch, A. Kohlberger, P. Gitsch, G. Kaider, A. Breitenecker, G. Kainz, C. Research Article The present study investigates the prognostic value of immunohistochemically detected cathepsin D expression in endometrial adenocarcinoma. Patients with surgically treated endometrial adenocarcinoma FIGO stages I-III and consecutive irradiation therapy were included in the study. When we performed immunohistochemistry to detect cathepsin D in 115 tissue specimens 35 cases showed a positive reaction. In the univariate analysis cathepsin D expression showed significant prognostic value for overall survival (P-value = 0.007). In the multivariate analysis with established prognostic parameters (stage, grade) we found an independent prognostic value for cathepsin D (P-value = 0.002, relative risk = 3.8, 95% confidence interval 1.4 - 10.0). Immunohistochemical detection of cathepsin D could aid in predicting prognosis and planning therapy for patients with endometrial adenocarcinoma. Nature Publishing Group 1996-06 /pmc/articles/PMC2074555/ /pubmed/8664123 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lösch, A. Kohlberger, P. Gitsch, G. Kaider, A. Breitenecker, G. Kainz, C.
spellingShingle	Lösch, A. Kohlberger, P. Gitsch, G. Kaider, A. Breitenecker, G. Kainz, C. Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
author_facet	Lösch, A. Kohlberger, P. Gitsch, G. Kaider, A. Breitenecker, G. Kainz, C.
author_sort	Lösch, A.
title	Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
title_short	Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
title_full	Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
title_fullStr	Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
title_full_unstemmed	Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
title_sort	lysosomal protease cathepsin d is a prognostic marker in endometrial cancer.
description	The present study investigates the prognostic value of immunohistochemically detected cathepsin D expression in endometrial adenocarcinoma. Patients with surgically treated endometrial adenocarcinoma FIGO stages I-III and consecutive irradiation therapy were included in the study. When we performed immunohistochemistry to detect cathepsin D in 115 tissue specimens 35 cases showed a positive reaction. In the univariate analysis cathepsin D expression showed significant prognostic value for overall survival (P-value = 0.007). In the multivariate analysis with established prognostic parameters (stage, grade) we found an independent prognostic value for cathepsin D (P-value = 0.002, relative risk = 3.8, 95% confidence interval 1.4 - 10.0). Immunohistochemical detection of cathepsin D could aid in predicting prognosis and planning therapy for patients with endometrial adenocarcinoma.
publisher	Nature Publishing Group
publishDate	1996
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074555/
_version_	1611407771623751680

Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.

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