Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.

The objectives of this study were to better our understanding of the carcinogenesis of gestational trophoblastic tumours and to investigate the possible presence of mutational alteration of the p53 tumour-suppressor gene in these tumours. Amplification-based direct DNA sequencing was performed on 14...

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Main Authors:	Shi, Y. F., Xie, X., Zhao, C. L., Ye, D. F., Lu, S. M., Hor, J. J., Pao, C. C.
Format:	Online
Language:	English
Published:	Nature Publishing Group 1996
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074525/

id	pubmed-2074525
recordtype	oai_dc
spelling	pubmed-20745252009-09-10 Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours. Shi, Y. F. Xie, X. Zhao, C. L. Ye, D. F. Lu, S. M. Hor, J. J. Pao, C. C. Research Article The objectives of this study were to better our understanding of the carcinogenesis of gestational trophoblastic tumours and to investigate the possible presence of mutational alteration of the p53 tumour-suppressor gene in these tumours. Amplification-based direct DNA sequencing was performed on 14 hydatidiform moles, six invasive moles, eight choriocarcinomas and ten normal early placental tissues. No mutation in exons 5-8 was detected in any of these 38 tissue specimens. These results suggest that a mutation in p53 tumour suppressor either does not exist or is a very rare event in gestational trophoblastic tumours. The gestational trophoblastic tumours probably involve a tumour-suppressor gene other than p53 gene or may follow a completely different pathway to their malignant phenotype. Nature Publishing Group 1996-05 /pmc/articles/PMC2074525/ /pubmed/8630281 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Shi, Y. F. Xie, X. Zhao, C. L. Ye, D. F. Lu, S. M. Hor, J. J. Pao, C. C.
spellingShingle	Shi, Y. F. Xie, X. Zhao, C. L. Ye, D. F. Lu, S. M. Hor, J. J. Pao, C. C. Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
author_facet	Shi, Y. F. Xie, X. Zhao, C. L. Ye, D. F. Lu, S. M. Hor, J. J. Pao, C. C.
author_sort	Shi, Y. F.
title	Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
title_short	Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
title_full	Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
title_fullStr	Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
title_full_unstemmed	Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
title_sort	lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.
description	The objectives of this study were to better our understanding of the carcinogenesis of gestational trophoblastic tumours and to investigate the possible presence of mutational alteration of the p53 tumour-suppressor gene in these tumours. Amplification-based direct DNA sequencing was performed on 14 hydatidiform moles, six invasive moles, eight choriocarcinomas and ten normal early placental tissues. No mutation in exons 5-8 was detected in any of these 38 tissue specimens. These results suggest that a mutation in p53 tumour suppressor either does not exist or is a very rare event in gestational trophoblastic tumours. The gestational trophoblastic tumours probably involve a tumour-suppressor gene other than p53 gene or may follow a completely different pathway to their malignant phenotype.
publisher	Nature Publishing Group
publishDate	1996
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074525/
_version_	1611407756926910464

Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.

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