Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

Neurotrophins, such as NGF and BDNF, induce sustained activation of Rap1 small G protein and ERK, which are essential for neurite outgrowth. We show involvement of a GDP/GTP exchange factor (GEF) for Rap1, PDZ-GEF1, in these processes. PDZ-GEF1 is activated by GTP-Rap1 via a positive feedback mechan...

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Bibliographic Details
Main Authors: Hisata, Shu, Sakisaka, Toshiaki, Baba, Takeshi, Yamada, Tomohiro, Aoki, Kazuhiro, Matsuda, Michiyuki, Takai, Yoshimi
Format: Online
Language:English
Published: The Rockefeller University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064548/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064548/

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