Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction

Dietary carotenoids are precursors for the production of retinoids, which participate in many essential processes, including the formation of the photopigment rhodopsin. Despite the importance of conversion of carotenoids to vitamin A (all-trans-retinol), many questions remain concerning the mechani...

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Main Authors:	Wang, Tao, Jiao, Yuchen, Montell, Craig
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2007
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064138/

id	pubmed-2064138
recordtype	oai_dc
spelling	pubmed-20641382007-11-29 Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction Wang, Tao Jiao, Yuchen Montell, Craig Research Articles Dietary carotenoids are precursors for the production of retinoids, which participate in many essential processes, including the formation of the photopigment rhodopsin. Despite the importance of conversion of carotenoids to vitamin A (all-trans-retinol), many questions remain concerning the mechanisms that promote this process, including the uptake of carotenoids. We use the Drosophila visual system as a genetic model to study retinoid formation from β-carotene. In a screen for mutations that affect the biosynthesis of rhodopsin, we identified a class B scavenger receptor, SANTA MARIA. We demonstrate that SANTA MARIA functions upstream of vitamin A formation in neurons and glia, which are outside of the retina. The protein is coexpressed and functionally coupled with the β, β-carotene-15, 15′-monooxygenase, NINAB, which converts β-carotene to all-trans-retinal. Another class B scavenger receptor, NINAD, functions upstream of SANTA MARIA in the uptake of carotenoids, enabling us to propose a pathway involving multiple extraretinal cell types and proteins essential for the formation of rhodopsin. The Rockefeller University Press 2007-04-23 /pmc/articles/PMC2064138/ /pubmed/17452532 http://dx.doi.org/10.1083/jcb.200610081 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wang, Tao Jiao, Yuchen Montell, Craig
spellingShingle	Wang, Tao Jiao, Yuchen Montell, Craig Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction
author_facet	Wang, Tao Jiao, Yuchen Montell, Craig
author_sort	Wang, Tao
title	Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction
title_short	Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction
title_full	Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction
title_fullStr	Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction
title_full_unstemmed	Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction
title_sort	dissection of the pathway required for generation of vitamin a and for drosophila phototransduction
description	Dietary carotenoids are precursors for the production of retinoids, which participate in many essential processes, including the formation of the photopigment rhodopsin. Despite the importance of conversion of carotenoids to vitamin A (all-trans-retinol), many questions remain concerning the mechanisms that promote this process, including the uptake of carotenoids. We use the Drosophila visual system as a genetic model to study retinoid formation from β-carotene. In a screen for mutations that affect the biosynthesis of rhodopsin, we identified a class B scavenger receptor, SANTA MARIA. We demonstrate that SANTA MARIA functions upstream of vitamin A formation in neurons and glia, which are outside of the retina. The protein is coexpressed and functionally coupled with the β, β-carotene-15, 15′-monooxygenase, NINAB, which converts β-carotene to all-trans-retinal. Another class B scavenger receptor, NINAD, functions upstream of SANTA MARIA in the uptake of carotenoids, enabling us to propose a pathway involving multiple extraretinal cell types and proteins essential for the formation of rhodopsin.
publisher	The Rockefeller University Press
publishDate	2007
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064138/
_version_	1611406455436476416

Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction

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