Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast

Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast

The telomere bouquet, i.e., telomere clustering on the nuclear envelope (NE) during meiotic prophase, is thought to promote homologous chromosome pairing. Using a visual screen, we identified bqt2/im295, a mutant that disrupts telomere clustering in fission yeast. Bqt2p is required for linking telom...

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Main Authors: Tang, Xie, Jin, Ye, Cande, W. Zacheus
Format: Online
Language:English
Published: The Rockefeller University Press 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063910/
id pubmed-2063910
recordtype oai_dc
spelling pubmed-20639102007-11-29 Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast Tang, Xie Jin, Ye Cande, W. Zacheus Research Articles The telomere bouquet, i.e., telomere clustering on the nuclear envelope (NE) during meiotic prophase, is thought to promote homologous chromosome pairing. Using a visual screen, we identified bqt2/im295, a mutant that disrupts telomere clustering in fission yeast. Bqt2p is required for linking telomeres to the meiotic spindle pole body (SPB) but not for attachment of telomeres or the SPB to the NE. Bqt2p is expressed upon pheromone sensing and colocalizes thereafter to Sad1p, an SPB protein. This localization only depends on Bqt1p, not on other identified proteins required for telomere clustering. Upon pheromone sensing, generation of Sad1p foci next to telomeres depends on Bqt2p. However, depletion of Bqt2p from the SPB is dispensable for dissolving the telomere bouquet at the end of meiotic prophase. Therefore, telomere bouquet formation requires Bqt2p as a linking component and is finely regulated during meiotic progression. The Rockefeller University Press 2006-06-19 /pmc/articles/PMC2063910/ /pubmed/16769823 http://dx.doi.org/10.1083/jcb.200602152 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Tang, Xie
Jin, Ye
Cande, W. Zacheus
spellingShingle Tang, Xie
Jin, Ye
Cande, W. Zacheus
Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast
author_facet Tang, Xie
Jin, Ye
Cande, W. Zacheus
author_sort Tang, Xie
title Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast
title_short Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast
title_full Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast
title_fullStr Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast
title_full_unstemmed Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast
title_sort bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast
description The telomere bouquet, i.e., telomere clustering on the nuclear envelope (NE) during meiotic prophase, is thought to promote homologous chromosome pairing. Using a visual screen, we identified bqt2/im295, a mutant that disrupts telomere clustering in fission yeast. Bqt2p is required for linking telomeres to the meiotic spindle pole body (SPB) but not for attachment of telomeres or the SPB to the NE. Bqt2p is expressed upon pheromone sensing and colocalizes thereafter to Sad1p, an SPB protein. This localization only depends on Bqt1p, not on other identified proteins required for telomere clustering. Upon pheromone sensing, generation of Sad1p foci next to telomeres depends on Bqt2p. However, depletion of Bqt2p from the SPB is dispensable for dissolving the telomere bouquet at the end of meiotic prophase. Therefore, telomere bouquet formation requires Bqt2p as a linking component and is finely regulated during meiotic progression.
publisher The Rockefeller University Press
publishDate 2006
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063910/
_version_ 1611406337293418496

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