Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.
We investigated the effects of low-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the incidence and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats fed a high-fat (HF) diet. We also examined the effects of these treatments on the fatty acid compo...
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| Format: | Online |
| Language: | English |
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Nature Publishing Group|1
1997
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063366/ |
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pubmed-20633662009-09-10 Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. Noguchi, M. Minami, M. Yagasaki, R. Kinoshita, K. Earashi, M. Kitagawa, H. Taniya, T. Miyazaki, I. Research Article We investigated the effects of low-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the incidence and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats fed a high-fat (HF) diet. We also examined the effects of these treatments on the fatty acid composition of tumour and serum. Tumour incidence was significantly decreased by the administration of low-dose EPA and DHA, whereas their inhibitory effects on tumour growth did not reach significance. Serum arachidonic acid (AA) level was decreased by the administration of low-dose EPA and tended to be decreased by the administration of low-dose DHA, whereas tumour AA levels were not changed. The administration of low-dose EPA and DHA may be useful for inhibiting the incidence of breast cancer. Nature Publishing Group|1 1997 /pmc/articles/PMC2063366/ /pubmed/9020478 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Noguchi, M. Minami, M. Yagasaki, R. Kinoshita, K. Earashi, M. Kitagawa, H. Taniya, T. Miyazaki, I. |
| spellingShingle |
Noguchi, M. Minami, M. Yagasaki, R. Kinoshita, K. Earashi, M. Kitagawa, H. Taniya, T. Miyazaki, I. Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. |
| author_facet |
Noguchi, M. Minami, M. Yagasaki, R. Kinoshita, K. Earashi, M. Kitagawa, H. Taniya, T. Miyazaki, I. |
| author_sort |
Noguchi, M. |
| title |
Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. |
| title_short |
Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. |
| title_full |
Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. |
| title_fullStr |
Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. |
| title_full_unstemmed |
Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. |
| title_sort |
chemoprevention of dmba-induced mammary carcinogenesis in rats by low-dose epa and dha. |
| description |
We investigated the effects of low-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the incidence and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats fed a high-fat (HF) diet. We also examined the effects of these treatments on the fatty acid composition of tumour and serum. Tumour incidence was significantly decreased by the administration of low-dose EPA and DHA, whereas their inhibitory effects on tumour growth did not reach significance. Serum arachidonic acid (AA) level was decreased by the administration of low-dose EPA and tended to be decreased by the administration of low-dose DHA, whereas tumour AA levels were not changed. The administration of low-dose EPA and DHA may be useful for inhibiting the incidence of breast cancer. |
| publisher |
Nature Publishing Group|1 |
| publishDate |
1997 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063366/ |
| _version_ |
1611406090620108800 |