Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1 inhibitors.
We have previously shown that loss of p53 function in A2780 human ovarian adenocarcinoma cells confers increased clonogenic resistance to several DNA-damaging agents, but not to taxol or camptothecin. We have now extended these studies, comparing wild-type p53-expressing A2780 cells with isogenic de...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group|1
1998
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062955/ |