Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study.

Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study.

The association between the intake of nitrate or nitrite and gastric cancer risk was investigated in a prospective cohort study started in 1986 in the Netherlands, of 120,852 men and women aged 55-69 years. At baseline, data on dietary intake, smoking habits and other covariates were collected by me...

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Main Authors: van Loon, A. J., Botterweck, A. A., Goldbohm, R. A., Brants, H. A., van Klaveren, J. D., van den Brandt, P. A.
Format: Online
Language:English
Published: Nature Publishing Group|1 1998
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062934/
id pubmed-2062934
recordtype oai_dc
spelling pubmed-20629342009-09-10 Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study. van Loon, A. J. Botterweck, A. A. Goldbohm, R. A. Brants, H. A. van Klaveren, J. D. van den Brandt, P. A. Research Article The association between the intake of nitrate or nitrite and gastric cancer risk was investigated in a prospective cohort study started in 1986 in the Netherlands, of 120,852 men and women aged 55-69 years. At baseline, data on dietary intake, smoking habits and other covariates were collected by means of a self-administered questionnaire. For data analysis, a case-cohort approach was used, in which the person-years at risk were estimated from a randomly selected subcohort (1688 men and 1812 women). After 6.3 years of follow-up, 282 microscopically confirmed incident cases of stomach cancer were detected: 219 men and 63 women. We did not find a higher risk of gastric cancer among people with a higher nitrate intake from food [rate ratio (RR) highest/lowest quintile = 0.80, 95% CI 0.47-1.37, trend-P = 0.18], a higher nitrate intake from drinking water (RR highest/lowest quintile = 0.88, 95% CI 0.59-1.32, trend-P = 0.39) or a higher intake of nitrite (RR highest/lowest quintile = 1.44, 95% CI 0.95-2.18, trend-P = 0.24). Rate ratios for gastric cancer were also computed for each tertile of nitrate intake from foods within tertiles of vitamin C intake and intake of beta-carotene, but no consistent pattern was found. Therefore, our study does not support a positive association between the intake of nitrate or nitrite and gastric cancer risk. Nature Publishing Group|1 1998-07 /pmc/articles/PMC2062934/ /pubmed/9662263 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author van Loon, A. J.
Botterweck, A. A.
Goldbohm, R. A.
Brants, H. A.
van Klaveren, J. D.
van den Brandt, P. A.
spellingShingle van Loon, A. J.
Botterweck, A. A.
Goldbohm, R. A.
Brants, H. A.
van Klaveren, J. D.
van den Brandt, P. A.
Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study.
author_facet van Loon, A. J.
Botterweck, A. A.
Goldbohm, R. A.
Brants, H. A.
van Klaveren, J. D.
van den Brandt, P. A.
author_sort van Loon, A. J.
title Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study.
title_short Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study.
title_full Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study.
title_fullStr Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study.
title_full_unstemmed Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study.
title_sort intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study.
description The association between the intake of nitrate or nitrite and gastric cancer risk was investigated in a prospective cohort study started in 1986 in the Netherlands, of 120,852 men and women aged 55-69 years. At baseline, data on dietary intake, smoking habits and other covariates were collected by means of a self-administered questionnaire. For data analysis, a case-cohort approach was used, in which the person-years at risk were estimated from a randomly selected subcohort (1688 men and 1812 women). After 6.3 years of follow-up, 282 microscopically confirmed incident cases of stomach cancer were detected: 219 men and 63 women. We did not find a higher risk of gastric cancer among people with a higher nitrate intake from food [rate ratio (RR) highest/lowest quintile = 0.80, 95% CI 0.47-1.37, trend-P = 0.18], a higher nitrate intake from drinking water (RR highest/lowest quintile = 0.88, 95% CI 0.59-1.32, trend-P = 0.39) or a higher intake of nitrite (RR highest/lowest quintile = 1.44, 95% CI 0.95-2.18, trend-P = 0.24). Rate ratios for gastric cancer were also computed for each tertile of nitrate intake from foods within tertiles of vitamin C intake and intake of beta-carotene, but no consistent pattern was found. Therefore, our study does not support a positive association between the intake of nitrate or nitrite and gastric cancer risk.
publisher Nature Publishing Group|1
publishDate 1998
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062934/
_version_ 1611405869213286400

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