Preparation and preclinical evaluation of humanised A33 immunoconjugates for radioimmunotherapy.
A humanised IgG1/k version of A33 (hA33) has been constructed and expressed with yields up to 700 mg l-1 in mouse myeloma NS0 cells in suspension culture. The equilibrium dissociation constant of hA33 (KD = 1.3 nM) was shown to be equivalent to that of the murine antibody in a cell-binding assay. hA...
| Main Authors: | , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
1995
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034099/ |