Hyperthermia, thermotolerance and topoisomerase II inhibitors.
The cytoxicity of both intercalating (m-AMSA) and non-intercalating (VP16, VM26) topoisomerase II-targeting drugs is thought to occur via trapping DNA topoisomerase II on DNA in the form of cleavable complexes. First, analysis of cleavable complexes (detected as DNA double-strand breaks) by pulsed-f...
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| Format: | Online |
| Language: | English |
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1995
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033976/ |