Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells.

Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells.

As an approach to the rational design of combination chemotherapy involving the anti-cancer DNA topoisomerase II poison etoposide (VP-16), we have studied the dynamic changes occurring in small-cell lung cancer (SCLC) cell populations during protracted VP-16 exposure. Cytometric methods were used to...

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Bibliographic Details
Main Authors:	Smith, P. J., Souès, S., Gottlieb, T., Falk, S. J., Watson, J. V., Osborne, R. J., Bleehen, N. M.
Format:	Online
Language:	English
Published:	1994
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033529/

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