Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
The selective cytotoxicity which Ro-07-0582 exhibits towards hypoxic cells is strongly temperature-dependent. This cytotoxicity is reduced by the radical scavenger cysteamine, suggesting that nitro radicals or nitroso intermediates are involved in cell killing by the drug. Chromosome aberrations are...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
1977
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025538/ |