Carcinoembryonic antigen in serum of unselected breast-cancer patients and of non-hospitalized controls.
A series of consecutive unselected patients with primary breast carcinoma and their age-matched controls were studied for serum CEA in relation to clinical findings. Raised CEA was found in a similar frequency in patients with primary breast cancer (pre- and postoperative) and in the control women:...
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| Format: | Online |
| Language: | English |
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1979
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009851/ |
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pubmed-2009851 |
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pubmed-20098512009-09-10 Carcinoembryonic antigen in serum of unselected breast-cancer patients and of non-hospitalized controls. Rimsten, A. Adami, H. O. Wahren, B. Nordin, B. Research Article A series of consecutive unselected patients with primary breast carcinoma and their age-matched controls were studied for serum CEA in relation to clinical findings. Raised CEA was found in a similar frequency in patients with primary breast cancer (pre- and postoperative) and in the control women: 16%, 11% and 11%, respectively, exceeded the selected upper limit of the reference range (13 ng/ml) with a double-antibody radioimmunoassay. In the breast-cancer patients, however, 48% of the raised CEA levels exceeded 16 ng/ml, compared with only 20% in the controls. Significant correlations (r approximately 0.3) were found between CEA levels and tumour size, TNM classification and a combined clinical and histopathological classification. A high frequency of raised CEA values in the advanced breast-cancer patients was the essential contribution to these positive correlations. A correlation coefficient of 0.6 was found between pre- and postoperative CEA values. The frequency of smoking and/or chronic disease was unexpectedly high in patients as well as in controls with high CEA. 1979-02 /pmc/articles/PMC2009851/ /pubmed/435362 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Rimsten, A. Adami, H. O. Wahren, B. Nordin, B. |
| spellingShingle |
Rimsten, A. Adami, H. O. Wahren, B. Nordin, B. Carcinoembryonic antigen in serum of unselected breast-cancer patients and of non-hospitalized controls. |
| author_facet |
Rimsten, A. Adami, H. O. Wahren, B. Nordin, B. |
| author_sort |
Rimsten, A. |
| title |
Carcinoembryonic antigen in serum of unselected breast-cancer patients and of non-hospitalized controls. |
| title_short |
Carcinoembryonic antigen in serum of unselected breast-cancer patients and of non-hospitalized controls. |
| title_full |
Carcinoembryonic antigen in serum of unselected breast-cancer patients and of non-hospitalized controls. |
| title_fullStr |
Carcinoembryonic antigen in serum of unselected breast-cancer patients and of non-hospitalized controls. |
| title_full_unstemmed |
Carcinoembryonic antigen in serum of unselected breast-cancer patients and of non-hospitalized controls. |
| title_sort |
carcinoembryonic antigen in serum of unselected breast-cancer patients and of non-hospitalized controls. |
| description |
A series of consecutive unselected patients with primary breast carcinoma and their age-matched controls were studied for serum CEA in relation to clinical findings. Raised CEA was found in a similar frequency in patients with primary breast cancer (pre- and postoperative) and in the control women: 16%, 11% and 11%, respectively, exceeded the selected upper limit of the reference range (13 ng/ml) with a double-antibody radioimmunoassay. In the breast-cancer patients, however, 48% of the raised CEA levels exceeded 16 ng/ml, compared with only 20% in the controls. Significant correlations (r approximately 0.3) were found between CEA levels and tumour size, TNM classification and a combined clinical and histopathological classification. A high frequency of raised CEA values in the advanced breast-cancer patients was the essential contribution to these positive correlations. A correlation coefficient of 0.6 was found between pre- and postoperative CEA values. The frequency of smoking and/or chronic disease was unexpectedly high in patients as well as in controls with high CEA. |
| publishDate |
1979 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009851/ |
| _version_ |
1611403284451426304 |