The natural history of antitumour immunity in human breast cancer assayed by tube leucocyte adherence inhibition.
The specificity of the tube LAI in breast cancer was examined in a study with coded samples of PBL. In addition, 64 patients with breast cancer had their LAI reactivity monitored and correlated with their clinical status for up to 3 years after mastectomy. When patients were assayed by tube LAI, 83,...
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| Format: | Online |
| Language: | English |
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1978
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009831/ |
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pubmed-2009831 |
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pubmed-20098312009-09-10 The natural history of antitumour immunity in human breast cancer assayed by tube leucocyte adherence inhibition. Lopez, M. O'Connor, R. MacFarlane, J. K. Thomson, D. M. Research Article The specificity of the tube LAI in breast cancer was examined in a study with coded samples of PBL. In addition, 64 patients with breast cancer had their LAI reactivity monitored and correlated with their clinical status for up to 3 years after mastectomy. When patients were assayed by tube LAI, 83, 72, and 29% with Stage I, and II and III breast cancer respectively were positive. In Stage IV brest cancer, 88% of those with local recurrence and 15% of those with disseminated cancer were positive. By contrast, 3% of control subjects were LAI+. A select group of patients admitted to hospital with suspicious breast lumps that histopathologically proved to be benign breast disease (BBD) had a higher incidence of LAI+ (12%), whereas of outpatients with BBD only 2% were LAI+. Most breast cancer patients LAI reactivity became negative 2--4 months after mastectomy, even when some harboured micrometastases. LAI reactivity remained absent in those patients who remained clinically "cancer-free". In the follow-up patients, LAI activity returned about 4 months before local recurrence. LAI reactivity was observed in 7/8 patients in the coded study and 14/15 patients in the follow-up study preceding and/or at the time of local recurrence. A few patients (15%) progressed to widespread cancer without preceding positive LAI activity. The results suggest that tumour-specific immunity rapidly fades after surgery and may play no role in the rejection of micrometastases by 6 months after surgery. In addition, the present study has shown that the human hose manifests tumour-specific immunity when the cancer is small, and suggests that the early detection of human cancer would depend upon reliable methods to measure the tumour-specific immune response. 1978-12 /pmc/articles/PMC2009831/ /pubmed/369585 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lopez, M. O'Connor, R. MacFarlane, J. K. Thomson, D. M. |
| spellingShingle |
Lopez, M. O'Connor, R. MacFarlane, J. K. Thomson, D. M. The natural history of antitumour immunity in human breast cancer assayed by tube leucocyte adherence inhibition. |
| author_facet |
Lopez, M. O'Connor, R. MacFarlane, J. K. Thomson, D. M. |
| author_sort |
Lopez, M. |
| title |
The natural history of antitumour immunity in human breast cancer assayed by tube leucocyte adherence inhibition. |
| title_short |
The natural history of antitumour immunity in human breast cancer assayed by tube leucocyte adherence inhibition. |
| title_full |
The natural history of antitumour immunity in human breast cancer assayed by tube leucocyte adherence inhibition. |
| title_fullStr |
The natural history of antitumour immunity in human breast cancer assayed by tube leucocyte adherence inhibition. |
| title_full_unstemmed |
The natural history of antitumour immunity in human breast cancer assayed by tube leucocyte adherence inhibition. |
| title_sort |
natural history of antitumour immunity in human breast cancer assayed by tube leucocyte adherence inhibition. |
| description |
The specificity of the tube LAI in breast cancer was examined in a study with coded samples of PBL. In addition, 64 patients with breast cancer had their LAI reactivity monitored and correlated with their clinical status for up to 3 years after mastectomy. When patients were assayed by tube LAI, 83, 72, and 29% with Stage I, and II and III breast cancer respectively were positive. In Stage IV brest cancer, 88% of those with local recurrence and 15% of those with disseminated cancer were positive. By contrast, 3% of control subjects were LAI+. A select group of patients admitted to hospital with suspicious breast lumps that histopathologically proved to be benign breast disease (BBD) had a higher incidence of LAI+ (12%), whereas of outpatients with BBD only 2% were LAI+. Most breast cancer patients LAI reactivity became negative 2--4 months after mastectomy, even when some harboured micrometastases. LAI reactivity remained absent in those patients who remained clinically "cancer-free". In the follow-up patients, LAI activity returned about 4 months before local recurrence. LAI reactivity was observed in 7/8 patients in the coded study and 14/15 patients in the follow-up study preceding and/or at the time of local recurrence. A few patients (15%) progressed to widespread cancer without preceding positive LAI activity. The results suggest that tumour-specific immunity rapidly fades after surgery and may play no role in the rejection of micrometastases by 6 months after surgery. In addition, the present study has shown that the human hose manifests tumour-specific immunity when the cancer is small, and suggests that the early detection of human cancer would depend upon reliable methods to measure the tumour-specific immune response. |
| publishDate |
1978 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009831/ |
| _version_ |
1611403275423186944 |