Haemoglobin C and S Role in Acquired Immunity against Plasmodium falciparum Malaria

A recently proposed mechanism of protection for haemoglobin C (HbC; β6Glu→Lys) links an abnormal display of PfEMP1, an antigen involved in malaria pathogenesis, on the surface of HbC infected erythrocytes together with the observation of reduced cytoadhesion of parasitized erythrocytes and impaired...

Full description

Bibliographic Details
Main Authors: Verra, Federica, Simpore, Jacques, Warimwe, George M., Tetteh, Kevin K., Howard, Tevis, Osier, Faith H. A., Bancone, Germana, Avellino, Pamela, Blot, Isa, Fegan, Greg, Bull, Peter C., Williams, Thomas N., Conway, David J., Marsh, Kevin, Modiano, David
Format: Online
Language:English
Published: Public Library of Science 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1991593/