Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.

Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.

Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate. All had relapsed from or failed to respond to primary endocrine treatment with orchidectomy or stilboestrol. Nineteen patients (48%) showed subjective...

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Main Authors: Ponder, B. A., Shearer, R. J., Pocock, R. D., Miller, J., Easton, D., Chilvers, C. E., Dowsett, M., Jeffcoate, S. L.
Format: Online
Language:English
Published: 1984
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977020/
id pubmed-1977020
recordtype oai_dc
spelling pubmed-19770202009-09-10 Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. Ponder, B. A. Shearer, R. J. Pocock, R. D. Miller, J. Easton, D. Chilvers, C. E. Dowsett, M. Jeffcoate, S. L. Research Article Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate. All had relapsed from or failed to respond to primary endocrine treatment with orchidectomy or stilboestrol. Nineteen patients (48%) showed subjective response, in most cases relief of bone pain. Side effects limited treatment in only 3 patients. We conclude that aminoglutethimide plus cortisone acetate is a useful addition to the treatment available for this difficult group of patients. The mechanism by which this treatment has a beneficial effect remains unclear. 1984-12 /pmc/articles/PMC1977020/ /pubmed/6238616 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Ponder, B. A.
Shearer, R. J.
Pocock, R. D.
Miller, J.
Easton, D.
Chilvers, C. E.
Dowsett, M.
Jeffcoate, S. L.
spellingShingle Ponder, B. A.
Shearer, R. J.
Pocock, R. D.
Miller, J.
Easton, D.
Chilvers, C. E.
Dowsett, M.
Jeffcoate, S. L.
Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
author_facet Ponder, B. A.
Shearer, R. J.
Pocock, R. D.
Miller, J.
Easton, D.
Chilvers, C. E.
Dowsett, M.
Jeffcoate, S. L.
author_sort Ponder, B. A.
title Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
title_short Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
title_full Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
title_fullStr Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
title_full_unstemmed Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
title_sort response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
description Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate. All had relapsed from or failed to respond to primary endocrine treatment with orchidectomy or stilboestrol. Nineteen patients (48%) showed subjective response, in most cases relief of bone pain. Side effects limited treatment in only 3 patients. We conclude that aminoglutethimide plus cortisone acetate is a useful addition to the treatment available for this difficult group of patients. The mechanism by which this treatment has a beneficial effect remains unclear.
publishDate 1984
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977020/
_version_ 1611400734322982912

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