The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour.

The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour.

Cytotoxic microspheres have been developed for intra-arterial use in patients with liver metastases. Following injection, the distribution of microspheres reflects the pattern of hepatic arterial blood-flow. Vasoactive agents, such as angiotensin II, by producing vasoconstriction in normal liver, mi...

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Main Authors: Goldberg, J. A., Murray, T., Kerr, D. J., Willmott, N., Bessent, R. G., McKillop, J. H., McArdle, C. S.
Format: Online
Language:English
Published: 1991
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971787/
id pubmed-1971787
recordtype oai_dc
spelling pubmed-19717872009-09-10 The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour. Goldberg, J. A. Murray, T. Kerr, D. J. Willmott, N. Bessent, R. G. McKillop, J. H. McArdle, C. S. Research Article Cytotoxic microspheres have been developed for intra-arterial use in patients with liver metastases. Following injection, the distribution of microspheres reflects the pattern of hepatic arterial blood-flow. Vasoactive agents, such as angiotensin II, by producing vasoconstriction in normal liver, might divert arterial blood toward tumour and thereby enhance the delivery of drug-loaded particles. Using a double isotope technique, the distribution of radiolabelled microspheres to tumour and normal liver tissue was measured before and after angiotensin II infusion in nine patients with multiple liver metastases. The median increase in tumour: normal ratio following angiotensin II infusion was by a factor of 2.8 (range 0.8-11.7, P less than 0.05). This novel approach to regional chemotherapy, using a combination of angiotensin II infusion and cytotoxic microspheres, increases the exposure of tumour to cytotoxic agents and may, therefore, enhance tumour response rates. 1991-02 /pmc/articles/PMC1971787/ /pubmed/1997111 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Goldberg, J. A.
Murray, T.
Kerr, D. J.
Willmott, N.
Bessent, R. G.
McKillop, J. H.
McArdle, C. S.
spellingShingle Goldberg, J. A.
Murray, T.
Kerr, D. J.
Willmott, N.
Bessent, R. G.
McKillop, J. H.
McArdle, C. S.
The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour.
author_facet Goldberg, J. A.
Murray, T.
Kerr, D. J.
Willmott, N.
Bessent, R. G.
McKillop, J. H.
McArdle, C. S.
author_sort Goldberg, J. A.
title The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour.
title_short The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour.
title_full The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour.
title_fullStr The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour.
title_full_unstemmed The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour.
title_sort use of angiotensin ii as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour.
description Cytotoxic microspheres have been developed for intra-arterial use in patients with liver metastases. Following injection, the distribution of microspheres reflects the pattern of hepatic arterial blood-flow. Vasoactive agents, such as angiotensin II, by producing vasoconstriction in normal liver, might divert arterial blood toward tumour and thereby enhance the delivery of drug-loaded particles. Using a double isotope technique, the distribution of radiolabelled microspheres to tumour and normal liver tissue was measured before and after angiotensin II infusion in nine patients with multiple liver metastases. The median increase in tumour: normal ratio following angiotensin II infusion was by a factor of 2.8 (range 0.8-11.7, P less than 0.05). This novel approach to regional chemotherapy, using a combination of angiotensin II infusion and cytotoxic microspheres, increases the exposure of tumour to cytotoxic agents and may, therefore, enhance tumour response rates.
publishDate 1991
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971787/
_version_ 1611400264572469248

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