Role of the semi-quinone free radical of the anti-tumour agent etoposide (VP-16-213) in the inactivation of single- and double-stranded phi X174 DNA.
The mechanism of action of the anti-tumour agent etoposide (VP-16-213) could involve its bioactivation to metabolites which can damage DNA. Active metabolites of etoposide, generated in vitro, are the 3',4'-dihydroxy-derivative (catechol) and its oxidation product, the ortho-quinone. The c...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
1990
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971739/ |