Products of vasopressin gene expression in small-cell carcinoma of the lung.

Small-cell neuroendocrine carcinoma of the lung is known to express products related to the vasopressin gene, although these products have been reported to sometimes differ from those generated by neurones of the hypothalamo-neurohypophyseal system. To further investigate vasopressin gene expression...

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Main Authors:	Friedmann, A. S., Malott, K. A., Memoli, V. A., Pai, S. I., Yu, X. M., North, W. G.
Format:	Online
Language:	English
Published:	1994
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968694/

id	pubmed-1968694
recordtype	oai_dc
spelling	pubmed-19686942009-09-10 Products of vasopressin gene expression in small-cell carcinoma of the lung. Friedmann, A. S. Malott, K. A. Memoli, V. A. Pai, S. I. Yu, X. M. North, W. G. Research Article Small-cell neuroendocrine carcinoma of the lung is known to express products related to the vasopressin gene, although these products have been reported to sometimes differ from those generated by neurones of the hypothalamo-neurohypophyseal system. To further investigate vasopressin gene expression in neuroendocrine carcinomas, we performed immunohistochemistry on 24 histologically classified small-cell carcinomas using antibodies directed against different regions of the vasopressin precursor. All of the tumours examined contained at least two parts of the vasopressin precursor, suggesting that vasopressin might have a biological role in these tumours and indicating a role for these products in tumour diagnosis and treatment. Sixty-seven per cent of the tumours contained immunoreactivity for all major regions of the precursor: vasopressin, vasopressin-associated human neurophysin, the bridging region between the hormone and the neurophysin, and vasopressin-associated human glycopeptide. However, 33% of the tumours examined appeared to express only part of the vasopressin precursor, as evidenced by the absence of immunoreactivity for the neurophysin and/or the glycopeptide. These results support the proposition that both normal and abnormal vasopressin gene expression occurs in small-cell carcinoma of the lung. 1994-02 /pmc/articles/PMC1968694/ /pubmed/8297723 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Friedmann, A. S. Malott, K. A. Memoli, V. A. Pai, S. I. Yu, X. M. North, W. G.
spellingShingle	Friedmann, A. S. Malott, K. A. Memoli, V. A. Pai, S. I. Yu, X. M. North, W. G. Products of vasopressin gene expression in small-cell carcinoma of the lung.
author_facet	Friedmann, A. S. Malott, K. A. Memoli, V. A. Pai, S. I. Yu, X. M. North, W. G.
author_sort	Friedmann, A. S.
title	Products of vasopressin gene expression in small-cell carcinoma of the lung.
title_short	Products of vasopressin gene expression in small-cell carcinoma of the lung.
title_full	Products of vasopressin gene expression in small-cell carcinoma of the lung.
title_fullStr	Products of vasopressin gene expression in small-cell carcinoma of the lung.
title_full_unstemmed	Products of vasopressin gene expression in small-cell carcinoma of the lung.
title_sort	products of vasopressin gene expression in small-cell carcinoma of the lung.
description	Small-cell neuroendocrine carcinoma of the lung is known to express products related to the vasopressin gene, although these products have been reported to sometimes differ from those generated by neurones of the hypothalamo-neurohypophyseal system. To further investigate vasopressin gene expression in neuroendocrine carcinomas, we performed immunohistochemistry on 24 histologically classified small-cell carcinomas using antibodies directed against different regions of the vasopressin precursor. All of the tumours examined contained at least two parts of the vasopressin precursor, suggesting that vasopressin might have a biological role in these tumours and indicating a role for these products in tumour diagnosis and treatment. Sixty-seven per cent of the tumours contained immunoreactivity for all major regions of the precursor: vasopressin, vasopressin-associated human neurophysin, the bridging region between the hormone and the neurophysin, and vasopressin-associated human glycopeptide. However, 33% of the tumours examined appeared to express only part of the vasopressin precursor, as evidenced by the absence of immunoreactivity for the neurophysin and/or the glycopeptide. These results support the proposition that both normal and abnormal vasopressin gene expression occurs in small-cell carcinoma of the lung.
publishDate	1994
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968694/
_version_	1611399796598243328

Products of vasopressin gene expression in small-cell carcinoma of the lung.

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