Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours.

Non-thyroid neoplasia were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10%-20% of human thyroid papillary c...

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Bibliographic Details
Main Authors: Santoro, M., Sabino, N., Ishizaka, Y., Ushijima, T., Carlomagno, F., Cerrato, A., Grieco, M., Battaglia, C., Martelli, M. L., Paulin, C.
Format: Online
Language:English
Published: 1993
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968385/
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Summary:Non-thyroid neoplasia were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10%-20% of human thyroid papillary carcinomas. None of 528 non-thyroid tumours showed rearrangement of the RET proto-oncogene, whereas three out of 30 thyroid papillary carcinomas were positive for RET activation. Therefore the activation of RET seems to be a somatic cell mutation specific to human thyroid carcinomas.