Growth arrest of the breast cancer cell line, T47D, by TNF alpha; cell cycle specificity and signal transduction.

The effects of tumour necrosis factor-alpha (TNF alpha) on the growth and DNA synthesis of the human breast cell line, T47D, were studied. A dose-dependent, reversible inhibition of thymidine incorporation and cell growth was observed in the range of 0.1 ng ml-1 to 100 ng ml-1 of TNF alpha. Cell via...

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Bibliographic Details
Main Authors: Pusztai, L., Lewis, C. E., McGee, J. O.
Format: Online
Language:English
Published: 1993
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968192/