Dosage and cycle effects of dacarbazine (DTIC) and fotemustine on O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells.
There is increasing experimental evidence to suggest that endogenous expression of O6-alkylguanine-DNA-alkyltransferase (ATase) is a major factor in cellular resistance to certain chemotherapeutic agents including dacarbazine (DTIC). We have recently shown wide interindividual variation in the deple...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
1993
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968172/ |