Post-Exposure Vaccination Improves Gammaherpesvirus Neutralization

Herpesvirus carriers transmit infection despite making virus-specific antibodies. Thus, their antibody responses are not necessarily optimal. An important question for infection control is whether vaccinating carriers might improve virus neutralization. The antibody response to murine gamma-herpesvi...

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Main Authors:	Gillet, Laurent, May, Janet S., Stevenson, Philip G.
Format:	Online
Language:	English
Published:	Public Library of Science 2007
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964807/

id	pubmed-1964807
recordtype	oai_dc
spelling	pubmed-19648072007-09-19 Post-Exposure Vaccination Improves Gammaherpesvirus Neutralization Gillet, Laurent May, Janet S. Stevenson, Philip G. Research Article Herpesvirus carriers transmit infection despite making virus-specific antibodies. Thus, their antibody responses are not necessarily optimal. An important question for infection control is whether vaccinating carriers might improve virus neutralization. The antibody response to murine gamma-herpesvirus-68 (MHV-68) blocks cell binding, but fails to block and even enhances an IgG Fc receptor-dependent infection of myeloid cells. Viral membrane fusion therefore remains intact. Although gH/gL-specific monoclonal antibodies can block infection at a post-binding step close to membrane fusion, gH/gL is a relatively minor antibody target in virus carriers. We show here that gH/gL-specific antibodies can block both Fc receptor-independent and Fc receptor-dependent infections, and that vaccinating virus carriers with a gH/gL fusion protein improves their capacity for virus neutralization both in vitro and in vivo. This approach has the potential to reduce herpesvirus transmission. Public Library of Science 2007-09-19 /pmc/articles/PMC1964807/ /pubmed/17878934 http://dx.doi.org/10.1371/journal.pone.0000899 Text en Gillet et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Gillet, Laurent May, Janet S. Stevenson, Philip G.
spellingShingle	Gillet, Laurent May, Janet S. Stevenson, Philip G. Post-Exposure Vaccination Improves Gammaherpesvirus Neutralization
author_facet	Gillet, Laurent May, Janet S. Stevenson, Philip G.
author_sort	Gillet, Laurent
title	Post-Exposure Vaccination Improves Gammaherpesvirus Neutralization
title_short	Post-Exposure Vaccination Improves Gammaherpesvirus Neutralization
title_full	Post-Exposure Vaccination Improves Gammaherpesvirus Neutralization
title_fullStr	Post-Exposure Vaccination Improves Gammaherpesvirus Neutralization
title_full_unstemmed	Post-Exposure Vaccination Improves Gammaherpesvirus Neutralization
title_sort	post-exposure vaccination improves gammaherpesvirus neutralization
description	Herpesvirus carriers transmit infection despite making virus-specific antibodies. Thus, their antibody responses are not necessarily optimal. An important question for infection control is whether vaccinating carriers might improve virus neutralization. The antibody response to murine gamma-herpesvirus-68 (MHV-68) blocks cell binding, but fails to block and even enhances an IgG Fc receptor-dependent infection of myeloid cells. Viral membrane fusion therefore remains intact. Although gH/gL-specific monoclonal antibodies can block infection at a post-binding step close to membrane fusion, gH/gL is a relatively minor antibody target in virus carriers. We show here that gH/gL-specific antibodies can block both Fc receptor-independent and Fc receptor-dependent infections, and that vaccinating virus carriers with a gH/gL fusion protein improves their capacity for virus neutralization both in vitro and in vivo. This approach has the potential to reduce herpesvirus transmission.
publisher	Public Library of Science
publishDate	2007
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964807/
_version_	1611399461645320192

Post-Exposure Vaccination Improves Gammaherpesvirus Neutralization

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