Delta–Notch—and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors
Hes and Hey genes are the mammalian counterparts of the Hairy and Enhancer-of-split type of genes in Drosophila and they represent the primary targets of the Delta–Notch signaling pathway. Hairy-related factors control multiple steps of embryonic development and misregulation is associated with vari...
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| Format: | Online |
| Language: | English |
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Oxford University Press
2007
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950541/ |
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pubmed-19505412007-08-22 Delta–Notch—and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors Fischer, Andreas Gessler, Manfred Molecular Biology Hes and Hey genes are the mammalian counterparts of the Hairy and Enhancer-of-split type of genes in Drosophila and they represent the primary targets of the Delta–Notch signaling pathway. Hairy-related factors control multiple steps of embryonic development and misregulation is associated with various defects. Hes and Hey genes (also called Hesr, Chf, Hrt, Herp or gridlock) encode transcriptional regulators of the basic helix-loop-helix class that mainly act as repressors. The molecular details of how Hes and Hey proteins control transcription are still poorly understood, however. Oxford University Press 2007-07 2007-06-22 /pmc/articles/PMC1950541/ /pubmed/17586813 http://dx.doi.org/10.1093/nar/gkm477 Text en © 2007 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Fischer, Andreas Gessler, Manfred |
| spellingShingle |
Fischer, Andreas Gessler, Manfred Delta–Notch—and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors |
| author_facet |
Fischer, Andreas Gessler, Manfred |
| author_sort |
Fischer, Andreas |
| title |
Delta–Notch—and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors |
| title_short |
Delta–Notch—and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors |
| title_full |
Delta–Notch—and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors |
| title_fullStr |
Delta–Notch—and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors |
| title_full_unstemmed |
Delta–Notch—and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors |
| title_sort |
delta–notch—and then? protein interactions and proposed modes of repression by hes and hey bhlh factors |
| description |
Hes and Hey genes are the mammalian counterparts of the Hairy and Enhancer-of-split type of genes in Drosophila and they represent the primary targets of the Delta–Notch signaling pathway. Hairy-related factors control multiple steps of embryonic development and misregulation is associated with various defects. Hes and Hey genes (also called Hesr, Chf, Hrt, Herp or gridlock) encode transcriptional regulators of the basic helix-loop-helix class that mainly act as repressors. The molecular details of how Hes and Hey proteins control transcription are still poorly understood, however. |
| publisher |
Oxford University Press |
| publishDate |
2007 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950541/ |
| _version_ |
1611399203663118336 |