Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics

Chromosome shaping and individualization are necessary requisites to warrant the correct segregation of genomes in either mitotic or meiotic cell divisions. These processes are mainly prompted in vertebrates by three multiprotein complexes termed cohesin and condensin I and II. In the present study...

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Main Authors:	Viera, Alberto, Gómez, Rocío, Parra, María T., Schmiesing, John A., Yokomori, Kyoko, Rufas, Julio S., Suja, José A.
Format:	Online
Language:	English
Published:	Public Library of Science 2007
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1942118/

id	pubmed-1942118
recordtype	oai_dc
spelling	pubmed-19421182007-08-22 Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics Viera, Alberto Gómez, Rocío Parra, María T. Schmiesing, John A. Yokomori, Kyoko Rufas, Julio S. Suja, José A. Research Article Chromosome shaping and individualization are necessary requisites to warrant the correct segregation of genomes in either mitotic or meiotic cell divisions. These processes are mainly prompted in vertebrates by three multiprotein complexes termed cohesin and condensin I and II. In the present study we have analyzed by immunostaining the appearance and subcellular distribution of condensin I in mouse mitotic and meiotic chromosomes. Our results demonstrate that in either mitotically or meiotically dividing cells, condensin I is loaded onto chromosomes by prometaphase. Condensin I is detectable as a fuzzy axial structure running inside chromatids of condensed chromosomes. The distribution of condensin I along the chromosome length is not uniform, since it preferentially accumulates close to the chromosome ends. Interestingly, these round accumulations found at the condensin I axes termini colocalized with telomere complexes. Additionally, we present the relative distribution of the condensin I and cohesin complexes in metaphase I bivalents. All these new data have allowed us to propose a comprehensive model for meiotic chromosome structure. Public Library of Science 2007-08-22 /pmc/articles/PMC1942118/ /pubmed/17712430 http://dx.doi.org/10.1371/journal.pone.0000783 Text en Viera et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Viera, Alberto Gómez, Rocío Parra, María T. Schmiesing, John A. Yokomori, Kyoko Rufas, Julio S. Suja, José A.
spellingShingle	Viera, Alberto Gómez, Rocío Parra, María T. Schmiesing, John A. Yokomori, Kyoko Rufas, Julio S. Suja, José A. Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics
author_facet	Viera, Alberto Gómez, Rocío Parra, María T. Schmiesing, John A. Yokomori, Kyoko Rufas, Julio S. Suja, José A.
author_sort	Viera, Alberto
title	Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics
title_short	Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics
title_full	Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics
title_fullStr	Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics
title_full_unstemmed	Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics
title_sort	condensin i reveals new insights on mouse meiotic chromosome structure and dynamics
description	Chromosome shaping and individualization are necessary requisites to warrant the correct segregation of genomes in either mitotic or meiotic cell divisions. These processes are mainly prompted in vertebrates by three multiprotein complexes termed cohesin and condensin I and II. In the present study we have analyzed by immunostaining the appearance and subcellular distribution of condensin I in mouse mitotic and meiotic chromosomes. Our results demonstrate that in either mitotically or meiotically dividing cells, condensin I is loaded onto chromosomes by prometaphase. Condensin I is detectable as a fuzzy axial structure running inside chromatids of condensed chromosomes. The distribution of condensin I along the chromosome length is not uniform, since it preferentially accumulates close to the chromosome ends. Interestingly, these round accumulations found at the condensin I axes termini colocalized with telomere complexes. Additionally, we present the relative distribution of the condensin I and cohesin complexes in metaphase I bivalents. All these new data have allowed us to propose a comprehensive model for meiotic chromosome structure.
publisher	Public Library of Science
publishDate	2007
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1942118/
_version_	1611398998386540544

Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics

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