Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens

Leishmania infection consists in two sequential events, the host cell colonization followed by the proliferation/dissemination of the parasite. In this review, we discuss the importance of two distinct sets of molecules, the secreted and/or surface and the nonsecreted antigens. The importance of the...

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Main Authors:	Santarém, Nuno, Silvestre, Ricardo, Tavares, Joana, Silva, Marta, Cabral, Sofia, Maciel, Joana, Cordeiro-da-Silva, Anabela
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2007
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940321/

id	pubmed-1940321
recordtype	oai_dc
spelling	pubmed-19403212007-08-20 Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens Santarém, Nuno Silvestre, Ricardo Tavares, Joana Silva, Marta Cabral, Sofia Maciel, Joana Cordeiro-da-Silva, Anabela Review Article Leishmania infection consists in two sequential events, the host cell colonization followed by the proliferation/dissemination of the parasite. In this review, we discuss the importance of two distinct sets of molecules, the secreted and/or surface and the nonsecreted antigens. The importance of the immune response against secreted and surface antigens is noted in the establishment of the infection and we dissect the contribution of the nonsecreted antigens in the immunopathology associated with leishmaniasis, showing the importance of these panantigens during the course of the infection. As a further example of proteins belonging to these two different groups, we include several laboratorial observations on Leishmania Sir2 and LicTXNPx as excreted/secreted proteins and LmS3arp and LimTXNPx as nonsecreted/panantigens. The role of these two groups of antigens in the immune response observed during the infection is discussed. Hindawi Publishing Corporation 2007 2007-06-27 /pmc/articles/PMC1940321/ /pubmed/17710243 http://dx.doi.org/10.1155/2007/85154 Text en Copyright © 2007 Nuno Santarém et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Santarém, Nuno Silvestre, Ricardo Tavares, Joana Silva, Marta Cabral, Sofia Maciel, Joana Cordeiro-da-Silva, Anabela
spellingShingle	Santarém, Nuno Silvestre, Ricardo Tavares, Joana Silva, Marta Cabral, Sofia Maciel, Joana Cordeiro-da-Silva, Anabela Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens
author_facet	Santarém, Nuno Silvestre, Ricardo Tavares, Joana Silva, Marta Cabral, Sofia Maciel, Joana Cordeiro-da-Silva, Anabela
author_sort	Santarém, Nuno
title	Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens
title_short	Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens
title_full	Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens
title_fullStr	Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens
title_full_unstemmed	Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens
title_sort	immune response regulation by leishmania secreted and nonsecreted antigens
description	Leishmania infection consists in two sequential events, the host cell colonization followed by the proliferation/dissemination of the parasite. In this review, we discuss the importance of two distinct sets of molecules, the secreted and/or surface and the nonsecreted antigens. The importance of the immune response against secreted and surface antigens is noted in the establishment of the infection and we dissect the contribution of the nonsecreted antigens in the immunopathology associated with leishmaniasis, showing the importance of these panantigens during the course of the infection. As a further example of proteins belonging to these two different groups, we include several laboratorial observations on Leishmania Sir2 and LicTXNPx as excreted/secreted proteins and LmS3arp and LimTXNPx as nonsecreted/panantigens. The role of these two groups of antigens in the immune response observed during the infection is discussed.
publisher	Hindawi Publishing Corporation
publishDate	2007
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940321/
_version_	1611398964093911040

Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens

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