Ageing, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity – catalysts of autoimmunity and chronic inflammation

Rheumatoid arthritis (RA), like many other autoimmune syndromes, is a disease of adults, with the highest incidence rates reported in the elderly. The immune system undergoes profound changes with advancing age that are beginning to be understood and that need to be incorporated into the pathogeneti...

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Bibliographic Details
Main Authors: Goronzy, Jörg J, Weyand, Cornelia M
Format: Online
Language:English
Published: BioMed Central 2003
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC193735/