Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin

Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin

HERG (human ether-à-go-go-related gene) encodes channels responsible for the cardiac rapid delayed rectifier potassium current, IKr. This study investigated the effects on HERG channels of doxepin, a tricyclic antidepressant linked to QT interval prolongation and cardiac arrhythmia. Whole-cell patch...

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Bibliographic Details
Main Authors: Duncan, R.S., McPate, M.J., Ridley, J.M., Gao, Z., James, A.F., Leishman, D.J., Leaney, J.L., Witchel, H.J., Hancox, J.C.
Format: Online
Language:English
Published: Elsevier Science 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920586/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920586/

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