PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes
Polyadenylation of nascent transcripts is one of the key mRNA processing events in eukaryotic cells. A large number of human and mouse genes have alternative polyadenylation sites, or poly(A) sites, leading to mRNA variants with different protein products and/or 3′-untranslated regions (3′-UTRs). Po...
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| Format: | Online |
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Oxford University Press
2007
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899096/ |
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pubmed-18990962007-06-26 PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes Lee, Ju Youn Yeh, Ijen Park, Ji Yeon Tian, Bin Articles Polyadenylation of nascent transcripts is one of the key mRNA processing events in eukaryotic cells. A large number of human and mouse genes have alternative polyadenylation sites, or poly(A) sites, leading to mRNA variants with different protein products and/or 3′-untranslated regions (3′-UTRs). PolyA_DB 2 contains poly(A) sites identified for genes in several vertebrate species, including human, mouse, rat, chicken and zebrafish, using alignments between cDNA/ESTs and genome sequences. Several new features have been added to the database since its last release, including syntenic genome regions for human poly(A) sites in seven other vertebrates and cis-element information adjacent to poly(A) sites. Trace sequences are used to provide additional evidence for poly(A/T) tails in cDNA/ESTs. The updated database is intended to broaden poly(A) site coverage in vertebrate genomes, and provide means to assess the authenticity of poly(A) sites identified by bioinformatics. The URL for this database is . Oxford University Press 2007-01 /pmc/articles/PMC1899096/ /pubmed/17202160 http://dx.doi.org/10.1093/nar/gkl870 Text en © 2006 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lee, Ju Youn Yeh, Ijen Park, Ji Yeon Tian, Bin |
| spellingShingle |
Lee, Ju Youn Yeh, Ijen Park, Ji Yeon Tian, Bin PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes |
| author_facet |
Lee, Ju Youn Yeh, Ijen Park, Ji Yeon Tian, Bin |
| author_sort |
Lee, Ju Youn |
| title |
PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes |
| title_short |
PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes |
| title_full |
PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes |
| title_fullStr |
PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes |
| title_full_unstemmed |
PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes |
| title_sort |
polya_db 2: mrna polyadenylation sites in vertebrate genes |
| description |
Polyadenylation of nascent transcripts is one of the key mRNA processing events in eukaryotic cells. A large number of human and mouse genes have alternative polyadenylation sites, or poly(A) sites, leading to mRNA variants with different protein products and/or 3′-untranslated regions (3′-UTRs). PolyA_DB 2 contains poly(A) sites identified for genes in several vertebrate species, including human, mouse, rat, chicken and zebrafish, using alignments between cDNA/ESTs and genome sequences. Several new features have been added to the database since its last release, including syntenic genome regions for human poly(A) sites in seven other vertebrates and cis-element information adjacent to poly(A) sites. Trace sequences are used to provide additional evidence for poly(A/T) tails in cDNA/ESTs. The updated database is intended to broaden poly(A) site coverage in vertebrate genomes, and provide means to assess the authenticity of poly(A) sites identified by bioinformatics. The URL for this database is . |
| publisher |
Oxford University Press |
| publishDate |
2007 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899096/ |
| _version_ |
1611397651419365376 |