Order-restricted inference for ordered gene expression (ORIOGEN) data under heteroscedastic variances

This article extends the order restricted inference approach for time-course or dose-response gene expression microarray data, introduced by Peddada and colleagues (2003) for the case when gene expression is heteroscedastic over time or dose. The new methodology uses an iterative algorithm to e...

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Bibliographic Details
Main Authors: Simmons, Susan J, Peddada, Shyamal D
Format: Online
Language:English
Published: Biomedical Informatics Publishing Group 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1896056/