Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma

The production of prostaglandins is regulated by cyclooxygenases (COXs), which also have a role in tumour development and progression in various human malignancies, including cholangiocarcinoma. Limited information is available of the correlation of COX-2 protein expression and prognosis in intrahep...

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Main Authors:	Schmitz, Klaus Jürgen, Lang, Hauke, Wohlschlaeger, Jeremias, Reis, Henning, Sotiropoulos, Georgios Charalambos, Schmid, Kurt Werner, Baba, Hideo Andreas
Format:	Online
Language:	English
Published:	Springer-Verlag 2006
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888720/

id	pubmed-1888720
recordtype	oai_dc
spelling	pubmed-18887202007-06-08 Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma Schmitz, Klaus Jürgen Lang, Hauke Wohlschlaeger, Jeremias Reis, Henning Sotiropoulos, Georgios Charalambos Schmid, Kurt Werner Baba, Hideo Andreas Original Article The production of prostaglandins is regulated by cyclooxygenases (COXs), which also have a role in tumour development and progression in various human malignancies, including cholangiocarcinoma. Limited information is available of the correlation of COX-2 protein expression and prognosis in intrahepatic cholangiocarcinoma (ICC). The aim of the present study was to determine the clinical significance of COX-2 expression in ICC. In addition the correlation of COX-2 expression and apoptosis/proliferation was analysed. COX-2 expression was determined immunohistochemically in 62 resected ICCs. Proliferation was assessed using Ki67-immunohistochemistry, and apoptosis was measured with the TdT-mediated dUTP nick-end-labelling technique. COX-2 was identified as an independent prognostic factor (P = 0.028) in resected ICC by survival analysis. High levels of COX-2 expression were found to be associated both with reduced apoptosis and increased proliferation of tumour cells. This study demonstrates the independent prognostic value of the COX-2 expression in resected ICC, thus, offering a potential additional adjuvant therapeutic approach with COX-2 inhibitors. Springer-Verlag 2006-12-13 2007-02 /pmc/articles/PMC1888720/ /pubmed/17165088 http://dx.doi.org/10.1007/s00428-006-0355-6 Text en © Springer-Verlag 2006
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Schmitz, Klaus Jürgen Lang, Hauke Wohlschlaeger, Jeremias Reis, Henning Sotiropoulos, Georgios Charalambos Schmid, Kurt Werner Baba, Hideo Andreas
spellingShingle	Schmitz, Klaus Jürgen Lang, Hauke Wohlschlaeger, Jeremias Reis, Henning Sotiropoulos, Georgios Charalambos Schmid, Kurt Werner Baba, Hideo Andreas Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma
author_facet	Schmitz, Klaus Jürgen Lang, Hauke Wohlschlaeger, Jeremias Reis, Henning Sotiropoulos, Georgios Charalambos Schmid, Kurt Werner Baba, Hideo Andreas
author_sort	Schmitz, Klaus Jürgen
title	Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma
title_short	Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma
title_full	Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma
title_fullStr	Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma
title_full_unstemmed	Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma
title_sort	elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma
description	The production of prostaglandins is regulated by cyclooxygenases (COXs), which also have a role in tumour development and progression in various human malignancies, including cholangiocarcinoma. Limited information is available of the correlation of COX-2 protein expression and prognosis in intrahepatic cholangiocarcinoma (ICC). The aim of the present study was to determine the clinical significance of COX-2 expression in ICC. In addition the correlation of COX-2 expression and apoptosis/proliferation was analysed. COX-2 expression was determined immunohistochemically in 62 resected ICCs. Proliferation was assessed using Ki67-immunohistochemistry, and apoptosis was measured with the TdT-mediated dUTP nick-end-labelling technique. COX-2 was identified as an independent prognostic factor (P = 0.028) in resected ICC by survival analysis. High levels of COX-2 expression were found to be associated both with reduced apoptosis and increased proliferation of tumour cells. This study demonstrates the independent prognostic value of the COX-2 expression in resected ICC, thus, offering a potential additional adjuvant therapeutic approach with COX-2 inhibitors.
publisher	Springer-Verlag
publishDate	2006
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888720/
_version_	1611397072693493760

Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma

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