Distance constraints between microRNA target sites dictate efficacy and cooperativity

MicroRNAs (miRNAs) have the potential to regulate the expression of thousands of genes, but the mechanisms that determine whether a gene is targeted or not are poorly understood. We studied the genomic distribution of distances between pairs of identical miRNA seeds and found a propensity for modera...

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Bibliographic Details
Main Authors: Sætrom, Pål, Heale, Bret S.E., Snøve, Ola, Aagaard, Lars, Alluin, Jessica, Rossi, John J.
Format: Online
Language:English
Published: Oxford University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874663/