Genetic Analysis Workshop 13: Simulated longitudinal data on families for a system of oligogenic traits

The Genetic Analysis Workshop 13 simulated data aimed to mimic the major features of the real Framingham Heart Study data that formed Problem 1, but under a known inheritance model and with 100 replicates, so as to allow evaluation of the statistical properties of various methods. The pedigrees used...

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Main Authors:	Daw, E Warwick, Morrison, John, Zhou, Xiaojun, Thomas, Duncan C
Format:	Online
Language:	English
Published:	BioMed Central 2003
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866465/

id	pubmed-1866465
recordtype	oai_dc
spelling	pubmed-18664652007-05-11 Genetic Analysis Workshop 13: Simulated longitudinal data on families for a system of oligogenic traits Daw, E Warwick Morrison, John Zhou, Xiaojun Thomas, Duncan C Proceedings The Genetic Analysis Workshop 13 simulated data aimed to mimic the major features of the real Framingham Heart Study data that formed Problem 1, but under a known inheritance model and with 100 replicates, so as to allow evaluation of the statistical properties of various methods. The pedigrees used were the 330 real pedigree structures (comprising 4692 individuals) with some minor changes to protect confidentiality. Fifty trait genes and 399 microsatellite markers were simulated by gene dropping on 22 autosomal chromosomes. Assuming random ascertainment of families, a system of eight longitudinal quantitative traits (designed to be similar to those in the real data) was generated with a wide range of heritabilities, including some pleiotropic and interactive effects. Genes could affect either the baseline level or the rate of change of the phenotype. Hypertension diagnosis and treatment were simulated with treatment availability, compliance, and efficacy depending on calendar year. Nongenetic traits of smoking and alcohol were generated as covariates for other traits. Death was simulated as a hazard rate depending upon age, sex, smoking, cholesterol, and systolic blood pressure. BioMed Central 2003-12-31 /pmc/articles/PMC1866465/ /pubmed/14975071 http://dx.doi.org/10.1186/1471-2156-4-S1-S3 Text en Copyright © 2003 Daw et al; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Daw, E Warwick Morrison, John Zhou, Xiaojun Thomas, Duncan C
spellingShingle	Daw, E Warwick Morrison, John Zhou, Xiaojun Thomas, Duncan C Genetic Analysis Workshop 13: Simulated longitudinal data on families for a system of oligogenic traits
author_facet	Daw, E Warwick Morrison, John Zhou, Xiaojun Thomas, Duncan C
author_sort	Daw, E Warwick
title	Genetic Analysis Workshop 13: Simulated longitudinal data on families for a system of oligogenic traits
title_short	Genetic Analysis Workshop 13: Simulated longitudinal data on families for a system of oligogenic traits
title_full	Genetic Analysis Workshop 13: Simulated longitudinal data on families for a system of oligogenic traits
title_fullStr	Genetic Analysis Workshop 13: Simulated longitudinal data on families for a system of oligogenic traits
title_full_unstemmed	Genetic Analysis Workshop 13: Simulated longitudinal data on families for a system of oligogenic traits
title_sort	genetic analysis workshop 13: simulated longitudinal data on families for a system of oligogenic traits
description	The Genetic Analysis Workshop 13 simulated data aimed to mimic the major features of the real Framingham Heart Study data that formed Problem 1, but under a known inheritance model and with 100 replicates, so as to allow evaluation of the statistical properties of various methods. The pedigrees used were the 330 real pedigree structures (comprising 4692 individuals) with some minor changes to protect confidentiality. Fifty trait genes and 399 microsatellite markers were simulated by gene dropping on 22 autosomal chromosomes. Assuming random ascertainment of families, a system of eight longitudinal quantitative traits (designed to be similar to those in the real data) was generated with a wide range of heritabilities, including some pleiotropic and interactive effects. Genes could affect either the baseline level or the rate of change of the phenotype. Hypertension diagnosis and treatment were simulated with treatment availability, compliance, and efficacy depending on calendar year. Nongenetic traits of smoking and alcohol were generated as covariates for other traits. Death was simulated as a hazard rate depending upon age, sex, smoking, cholesterol, and systolic blood pressure.
publisher	BioMed Central
publishDate	2003
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866465/
_version_	1611396205666893824

Genetic Analysis Workshop 13: Simulated longitudinal data on families for a system of oligogenic traits

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