No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese

No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese

Recent studies have suggested that Helicobacter pylori (H. pylori) infection might be a risk factor for atherosclerosis. Since the bacterium has not been isolated from atherosclerotic lesions, a direct role in atherogenesis is not plausible. We examined associations of plasma total homocysteine (tHc...

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Main Authors: Itou, Simon, Goto, Yasuyuki, Kondo, Takaaki, Nishio, Kazuko, Kawai, Sayo, Ishida, Yoshiko, Naito, Mariko, Hamajima, Nobuyuki
Format: Online
Language:English
Published: Ivyspring International Publisher 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838822/
id pubmed-1838822
recordtype oai_dc
spelling pubmed-18388222007-03-29 No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese Itou, Simon Goto, Yasuyuki Kondo, Takaaki Nishio, Kazuko Kawai, Sayo Ishida, Yoshiko Naito, Mariko Hamajima, Nobuyuki Research Paper Recent studies have suggested that Helicobacter pylori (H. pylori) infection might be a risk factor for atherosclerosis. Since the bacterium has not been isolated from atherosclerotic lesions, a direct role in atherogenesis is not plausible. We examined associations of plasma total homocysteine (tHcy) and serum folate, independent risk factors for atherosclerosis, with H. pylori infection and subsequent gastric atrophy among 174 patients (78 males and 96 females) aged 20 to 73 years, who visited an H. pylori eradication clinic of Nagoya University from July 2004 to October 2005. Polymorphism genotyping was conducted for methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) 28-bp tandem repeats by PCR with confronting two-pair primers and PCR, respectively. H. pylori infection and gastric atrophy were not significantly associated with hyperhomocysteinemia (tHcy ≥ 12 nmol/ml), when adjusted by sex, age, smoking, alcohol, and genotypes of MTHFR and TS. The adjusted odds ratio of gastric atrophy for low folate level (≤ 4mg/ml) was 0.21 (95% confidence interval = 0.05-0.78). The associations of tHcy with serum folate and MTHFR genotype were clearly observed in this dataset. The present study demonstrated that folate and MTHFR genotype were the deterministic factors of plasma tHcy, but not H. pylori infection and subsequent gastric atrophy, indicating that even if H. pylori infection influences the risk of atherosclerosis, the influence may not be through the elevation of homocysteine. Ivyspring International Publisher 2007-03-14 /pmc/articles/PMC1838822/ /pubmed/17396161 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Itou, Simon
Goto, Yasuyuki
Kondo, Takaaki
Nishio, Kazuko
Kawai, Sayo
Ishida, Yoshiko
Naito, Mariko
Hamajima, Nobuyuki
spellingShingle Itou, Simon
Goto, Yasuyuki
Kondo, Takaaki
Nishio, Kazuko
Kawai, Sayo
Ishida, Yoshiko
Naito, Mariko
Hamajima, Nobuyuki
No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese
author_facet Itou, Simon
Goto, Yasuyuki
Kondo, Takaaki
Nishio, Kazuko
Kawai, Sayo
Ishida, Yoshiko
Naito, Mariko
Hamajima, Nobuyuki
author_sort Itou, Simon
title No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese
title_short No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese
title_full No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese
title_fullStr No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese
title_full_unstemmed No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese
title_sort no associations of helicobacter pylori infection and gastric atrophy with plasma total homocysteine in japanese
description Recent studies have suggested that Helicobacter pylori (H. pylori) infection might be a risk factor for atherosclerosis. Since the bacterium has not been isolated from atherosclerotic lesions, a direct role in atherogenesis is not plausible. We examined associations of plasma total homocysteine (tHcy) and serum folate, independent risk factors for atherosclerosis, with H. pylori infection and subsequent gastric atrophy among 174 patients (78 males and 96 females) aged 20 to 73 years, who visited an H. pylori eradication clinic of Nagoya University from July 2004 to October 2005. Polymorphism genotyping was conducted for methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) 28-bp tandem repeats by PCR with confronting two-pair primers and PCR, respectively. H. pylori infection and gastric atrophy were not significantly associated with hyperhomocysteinemia (tHcy ≥ 12 nmol/ml), when adjusted by sex, age, smoking, alcohol, and genotypes of MTHFR and TS. The adjusted odds ratio of gastric atrophy for low folate level (≤ 4mg/ml) was 0.21 (95% confidence interval = 0.05-0.78). The associations of tHcy with serum folate and MTHFR genotype were clearly observed in this dataset. The present study demonstrated that folate and MTHFR genotype were the deterministic factors of plasma tHcy, but not H. pylori infection and subsequent gastric atrophy, indicating that even if H. pylori infection influences the risk of atherosclerosis, the influence may not be through the elevation of homocysteine.
publisher Ivyspring International Publisher
publishDate 2007
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838822/
_version_ 1611395328414580736

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