A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes

Drosophila melanogaster, like other invertebrates, relies solely on its innate immune response to fight invading microbes; by definition, innate immunity lacks adaptive characteristics. However, we show here that priming Drosophila with a sublethal dose of Streptococcus pneumoniae protects against...

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Main Authors:	Pham, Linh N, Dionne, Marc S, Shirasu-Hiza, Mimi, Schneider, David S
Format:	Online
Language:	English
Published:	Public Library of Science 2007
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1817657/

id	pubmed-1817657
recordtype	oai_dc
spelling	pubmed-18176572007-03-30 A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes Pham, Linh N Dionne, Marc S Shirasu-Hiza, Mimi Schneider, David S Research Article Drosophila melanogaster, like other invertebrates, relies solely on its innate immune response to fight invading microbes; by definition, innate immunity lacks adaptive characteristics. However, we show here that priming Drosophila with a sublethal dose of Streptococcus pneumoniae protects against an otherwise-lethal second challenge of S. pneumoniae. This protective effect exhibits coarse specificity for S. pneumoniae and persists for the life of the fly. Although not all microbial challenges induced this specific primed response, we find that a similar specific protection can be elicited by Beauveria bassiana, a natural fly pathogen. To characterize this primed response, we focused on S. pneumoniae–induced protection. The mechanism underlying this protective effect requires phagocytes and the Toll pathway. However, activation of the Toll pathway is not sufficient for priming-induced protection. This work contradicts the paradigm that insect immune responses cannot adapt and will promote the search for similar responses overlooked in organisms with an adaptive immune response. Public Library of Science 2007-03 2007-03-09 /pmc/articles/PMC1817657/ /pubmed/17352533 http://dx.doi.org/10.1371/journal.ppat.0030026 Text en © 2007 Pham et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Pham, Linh N Dionne, Marc S Shirasu-Hiza, Mimi Schneider, David S
spellingShingle	Pham, Linh N Dionne, Marc S Shirasu-Hiza, Mimi Schneider, David S A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes
author_facet	Pham, Linh N Dionne, Marc S Shirasu-Hiza, Mimi Schneider, David S
author_sort	Pham, Linh N
title	A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes
title_short	A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes
title_full	A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes
title_fullStr	A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes
title_full_unstemmed	A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes
title_sort	specific primed immune response in drosophila is dependent on phagocytes
description	Drosophila melanogaster, like other invertebrates, relies solely on its innate immune response to fight invading microbes; by definition, innate immunity lacks adaptive characteristics. However, we show here that priming Drosophila with a sublethal dose of Streptococcus pneumoniae protects against an otherwise-lethal second challenge of S. pneumoniae. This protective effect exhibits coarse specificity for S. pneumoniae and persists for the life of the fly. Although not all microbial challenges induced this specific primed response, we find that a similar specific protection can be elicited by Beauveria bassiana, a natural fly pathogen. To characterize this primed response, we focused on S. pneumoniae–induced protection. The mechanism underlying this protective effect requires phagocytes and the Toll pathway. However, activation of the Toll pathway is not sufficient for priming-induced protection. This work contradicts the paradigm that insect immune responses cannot adapt and will promote the search for similar responses overlooked in organisms with an adaptive immune response.
publisher	Public Library of Science
publishDate	2007
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1817657/
_version_	1611394861301235712

A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes

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