Modification of a Hydrophobic Layer by a Point Mutation in Syntaxin 1A Regulates the Rate of Synaptic Vesicle Fusion

Both constitutive secretion and Ca2+-regulated exocytosis require the assembly of the soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) complexes. At present, little is known about how the SNARE complexes mediating these two distinct pathways differ in structure. Using th...

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Bibliographic Details
Main Authors: Lagow, Robert D, Bao, Hong, Cohen, Evan N, Daniels, Richard W, Zuzek, Aleksej, Williams, Wade H, Macleod, Gregory T, Sutton, R. Bryan, Zhang, Bing
Format: Online
Language:English
Published: Public Library of Science 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808484/