The Role of Citrullinated Proteins Suggests a Novel Mechanism in the Pathogenesis of Multiple Sclerosis
The pathogenesis of MS is unknown. In our studies, we have demonstrated an important role for citrullinated myelin basic protein (MBP). The accompanying loss of positive charge compromises the ability of MBP to interact with the lipid bilayer. The conversion of arginine to citrulline in brain is car...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Kluwer Academic Publishers-Plenum Publishers
2006
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794624/ |