Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues.

Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues.

The present study was performed to: (a) evaluate the effects of kinin B1 (Sar[D-Phe8]-des-Arg9-BK; 10 nmol/kg) and B2 (bradykinin (BK); 10 nmol/kg) receptor agonists on plasma extravasation in selected rat tissues; (b) determine the contribution of a lipopolysaccharide (LPS) (100 microg/kg) to the e...

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Main Authors: Wille, P R, Vitor, R, Gabilan, N H, Nicolau, M
Format: Online
Language:English
Published: 2001
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781703/
id pubmed-1781703
recordtype oai_dc
spelling pubmed-17817032007-01-25 Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues. Wille, P R Vitor, R Gabilan, N H Nicolau, M Research Article The present study was performed to: (a) evaluate the effects of kinin B1 (Sar[D-Phe8]-des-Arg9-BK; 10 nmol/kg) and B2 (bradykinin (BK); 10 nmol/kg) receptor agonists on plasma extravasation in selected rat tissues; (b) determine the contribution of a lipopolysaccharide (LPS) (100 microg/kg) to the effects triggered by B1 and B2 agonists; and (c) characterize the selectivity of B1 ([Leu8]desArg9-BK; 10 nmol/kg) and B2 (HOE 140; 10 nmol/kg) antagonists as inhibitors of this kinin-induced phenomenon. B1 and B2 agonists were shown to increase plasma extravasation in the duodenum, ileum and also in the urinary bladder of the rat. LPS pretreatment enhanced the plasma extravasation mediated only by the B1 agonist in the duodenum, ileum, trachea, main and segmentar bronchi. These effects were prevented by the B1. but not the B2 antagonist. In normal rats, the B2 antagonist inhibited the effect of B2 agonist in all the tissues analyzed. However, in LPS-treated rats, the B2 antagonist was ineffective in the urinary bladder. These results indicate that kinins induce plasma extravasation in selected rat tissues through activation of B1 and B2 receptors, and that LPS selectively enhances the kinin effect on the B1 receptor in the duodenum, ileum, trachea and main and segmentar bronchi, and may increase B1 receptor expression in these tissues. 2001-06 /pmc/articles/PMC1781703/ /pubmed/11545253 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Wille, P R
Vitor, R
Gabilan, N H
Nicolau, M
spellingShingle Wille, P R
Vitor, R
Gabilan, N H
Nicolau, M
Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues.
author_facet Wille, P R
Vitor, R
Gabilan, N H
Nicolau, M
author_sort Wille, P R
title Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues.
title_short Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues.
title_full Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues.
title_fullStr Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues.
title_full_unstemmed Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues.
title_sort plasma extravasation mediated by lipopolysaccharide-induction of kinin b1 receptors in rat tissues.
description The present study was performed to: (a) evaluate the effects of kinin B1 (Sar[D-Phe8]-des-Arg9-BK; 10 nmol/kg) and B2 (bradykinin (BK); 10 nmol/kg) receptor agonists on plasma extravasation in selected rat tissues; (b) determine the contribution of a lipopolysaccharide (LPS) (100 microg/kg) to the effects triggered by B1 and B2 agonists; and (c) characterize the selectivity of B1 ([Leu8]desArg9-BK; 10 nmol/kg) and B2 (HOE 140; 10 nmol/kg) antagonists as inhibitors of this kinin-induced phenomenon. B1 and B2 agonists were shown to increase plasma extravasation in the duodenum, ileum and also in the urinary bladder of the rat. LPS pretreatment enhanced the plasma extravasation mediated only by the B1 agonist in the duodenum, ileum, trachea, main and segmentar bronchi. These effects were prevented by the B1. but not the B2 antagonist. In normal rats, the B2 antagonist inhibited the effect of B2 agonist in all the tissues analyzed. However, in LPS-treated rats, the B2 antagonist was ineffective in the urinary bladder. These results indicate that kinins induce plasma extravasation in selected rat tissues through activation of B1 and B2 receptors, and that LPS selectively enhances the kinin effect on the B1 receptor in the duodenum, ileum, trachea and main and segmentar bronchi, and may increase B1 receptor expression in these tissues.
publishDate 2001
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781703/
_version_ 1611393551724183552

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