Analysis of In-Vivo LacR-Mediated Gene Repression Based on the Mechanics of DNA Looping
Interactions of E. coli lac repressor (LacR) with a pair of operator sites on the same DNA molecule can lead to the formation of looped nucleoprotein complexes both in vitro and in vivo. As a major paradigm for loop-mediated gene regulation, parameters such as operator affinity and spacing, represso...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2006
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762422/ |