Critical Role of Methylglyoxal and AGE in Mycobacteria-Induced Macrophage Apoptosis and Activation

Critical Role of Methylglyoxal and AGE in Mycobacteria-Induced Macrophage Apoptosis and Activation

Apoptosis and activation of macrophages play an important role in the host response to mycobacterial infection involving TNF-α as a critical autocrine mediator. The underlying mechanisms are still ill-defined. Here, we demonstrate elevated levels of methylglyoxal (MG), a small and reactive molecule...

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Main Authors: Rachman, Helmy, Kim, Nayoung, Ulrichs, Timo, Baumann, Sven, Pradl, Lydia, Eddine, Ali Nasser, Bild, Matthias, Rother, Marion, Kuban, Ralf-Jürgen, Lee, Jong Seok, Hurwitz, Robert, Brinkmann, Volker, Kosmiadi, George A., Kaufmann, Stefan H.E.
Format: Online
Language:English
Published: Public Library of Science 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762319/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762319/

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